Nifalatide hydrochloride, BW-942C
L-酪氨酰-D-蛋氨酰甘氨酰-4-硝基苯基丙氨酰-L-脯氨酸酰胺S-氧化盐酸 尼法那塔 Chemical Name: L-Tyrosyl-D-methionylglycyl-4-nitrophenylalanyl-L-prolinamide S-oxide hydrochloride; L-Tyrosyl-gamma-(methylsulfinyl)-D-alpha-aminobutyrylglycyl-4-nitro-L-phenylalanyl-L-prolinamide hydrochloride
CAS No. 98311-64-9, 73385-60-1 (free base)
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator)
合成路线:The condensation of tert-butoxycarbonyltyrosine (I) with methionylglycine methyl ester S-oxide (II) gives the protected tripeptide (III),which is saponified to tert-butoxycarbonyltyrosyl-methionylglycine S-oxide (IV).The condensation of (IV) with 4-nitrophenylalanyl-prolinamide (V) yields the protected tripeptide (VI),which is finally deprotected as usual.
📌 参考资料/链接：
参考文献标题:Treatment of diarrhoea and dysentery
文献作者:Wilkinson,S.(Glaxo Wellcome Inc.)
参考来源:JP 7992938
📄 详细内容
合成路线:The condensation of tert-butoxycarbonyltyrosine (I) with methionylglycine methyl ester S-oxide (II) gives the protected tripeptide (III),which is saponified to tert-butoxycarbonyltyrosyl-methionylglycine S-oxide (IV).The condensation of (IV) with 4-nitrophenylalanyl-prolinamide (V) yields the protected tripeptide (VI),which is finally deprotected as usual.
参考文献标题:Nifalatide hydrochloride
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(8),657
产品链接: CAS No. 98311-64-9›› 产品链接: CAS No.73385-60-1››