KNK-437

KNK437(热激蛋白抑制剂I)Chemical Name: 3-[(E)-1,3-Benzodioxol-5-ylmethylene]-2-oxopyrrolidine-1-carbaldehyde
CAS No. 218924-25-5
项目整合开发状态: Preclinical
项目研究机构: Kaneka (Originator)
合成路线:Condensation of piperonal (I) with N-acetyl-2-pyrrolidone (II) in the presence of NaH in THF afforded the benzylidene pyrrolidone (III).The title formamide was then obtained upon refluxing of (III) with formic acid with azeotropical removal of water.