HA-1004
HA-1004二盐酸盐Chemical Name: N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide hydrochloride
CAS No. 91742-10-8
项目整合开发状态: Phase II
项目研究机构: Asahi Kasei (Originator), Mie University (Originator)
合成路线:The reaction of 5-isoquinolinesulfonyl chloride (I) with ethyldiamine (II) in methylene chloride gives N-(2-aminoethyl)isoquinoline-5-sulfonamide (III),which is then condensed with S-methylisothiourea sulfate (IV) by means of NaOH at 80 C.
📌 参考资料/链接：
参考文献标题:HA-1004
文献作者:Koch,H.; Castar,J.
参考来源:Drugs Fut 1985,10(10),815
📄 详细内容
合成路线:The reaction of 5-isoquinolinesulfonyl chloride (I) with ethyldiamine (II) in methylene chloride gives N-(2-aminoethyl)isoquinoline-5-sulfonamide (III),which is then condensed with S-methylisothiourea sulfate (IV) by means of NaOH at 80 C.
参考文献标题:Vasodilatory action of HA-1004 [N-(2-guanidinoethyl)-5-isoquinolinesulfonamide],a novel calcium antagonist with no efect on cardiac function
文献作者:Asano,T.; Hidaka,H.
参考来源:J Pharmacol Exp Ther 1984,231(1),141
产品链接: CAS No. 91742-10-8››