PD-166866
FGFR1酪氨酸激酶抑制剂(PD-166866)Chemical Name: N-[2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(tert-butyl)urea
CAS No. 192705-79-6
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:Condensation of pyrimidine carboxaldehyde (I) with 3,5-dimethoxy-phenylacetonitrile (II) using NaH in 2-ethoxyethanol provided the pyridopyrimidine (III).Then,regioselective condensation of (III) with tert-butyl isocyanate at the 7-amino group in the presence of NaH in DMF furnished the corresponding urea.
📌 参考资料/链接：
参考文献标题:Structure-activity relationships for a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors
文献作者:Hamby,J.M.; Connolly,C.J.C.; Schroeder,M.C.; Winters,R.T.; Showalter,H.D.; Panek,R.L.; Major,T.C.; Olsewski,B.; Ryan,M.J.; Dahring,T.K.; Lu,G.H.; Keiser,J.A.; Amar,A.M.; Shen,C.; Kraker,A.J.; Slintak,V.; Nelson,J.M.; Fry,D.W.; et al.
参考来源:J Med Chem 1997,40(15),2296
📄 详细内容
合成路线:Condensation of pyrimidine carboxaldehyde (I) with 3,5-dimethoxy-phenylacetonitrile (II) using NaH in 2-ethoxyethanol provided the pyridopyrimidine (III).Then,regioselective condensation of (III) with tert-butyl isocyanate at the 7-amino group in the presence of NaH in DMF furnished the corresponding urea.
参考文献标题:Discovery and structure-activity studies of a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors
文献作者:Hamby,J.M.; Connolly,C.J.C.; Schroeder,M.C.; et al.
参考来源:Bioorg Med Chem Lett 1997,7(18),2415
产品链接: CAS No. 192705-79-6››