BIOLF-70
9-[1,3-二(苯基甲氧基)丙-2-基氧基甲基]-6-氯嘌呤-2-胺Chemical Name: 9-[2-(Benzyloxy)-1-(benzyloxymethyl)ethoxymethyl]-6-chloro-9H-purin-2-amine
CAS No. 84222-47-9
项目整合开发状态: Preclinical
项目研究机构: ENS Biologicals (Originator), McGill University (Originator), Roche Bioscience (Licensee)
合成路线:By the condensation of 2-amino-6-chloropurine (I) (which has been silylated with 1,1,1,3,3,3-hexamethyldisilazane) with (1,3-dibenzyloxy-2-propoxy)methyl chloride (II) by means of mercuric cyanide in benzene at reflux.BIOLF-7O is purified by chromatography over silica gel.
📌 参考资料/链接：
参考文献标题:BIOLF-70
文献作者:Ogilvie,K.K.; Gauntt,C.J.
参考来源:Drugs Fut 1986,11(10),826
📄 详细内容
合成路线:By the condensation of 2-amino-6-chloropurine (I) (which has been silylated with 1,1,1,3,3,3-hexamethyldisilazane) with (1,3-dibenzyloxy-2-propoxy)methyl chloride (II) by means of mercuric cyanide in benzene at reflux.BIOLF-7O is purified by chromatography over silica gel.
参考文献标题:Biologically active acylnucleoside analogues.II.The synthesis of 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine (BIOLF-62)
文献作者:Smith,K.O.; Kennell,W.L.; Galloway,K.S.; Cheriyan,U.O.; Ogilvie,K.K.; Radatus,B.K.
参考来源:Can J Chem 1982,603005
产品链接: CAS No. 84222-47-9››