KP-136, AL-136

8-己氧基-3-(2H-四唑-5-基)苯并吡喃-2-酮Chemical Name: 8-Hexyloxy-3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-one
CAS No. 76239-32-2
项目整合开发状态: Phase II
项目研究机构: Kaken (Originator)
合成路线:The demethylation ot o-vanillin (I) with AlCl3 dissolved in pyridine gives 2,3 dihydroxybenzaldehyde (II).Subsequent alkylation by means of hexyl bromide with NaH gives 3-hexyloxy-2-hydroxybenzaldehyde (III),which is then condensed with malononitrile and piperidine,yielding 3-cyano-8-hexyloxycromen-2-one (IV),a needle-like yellow crystalline substance.Finally,compound (IV) is treated with sodium azide and AlCl3 in refluxing THF,yielding the formation of the tetrazole ring.