FR-236924
8-{2-[(2-戊基环丙基)甲基]环丙基}辛酸Chemical Name: 8-[2-(2-Pentylcyclopropylmethyl)cyclopropyl]octanoic acid
CAS No. 28399-31-7
项目整合开发状态: Preclinical
项目研究机构: Fujisawa (Originator)
合成路线:Cyclopropanation of linoleic acid methyl ester (I) employing diiodomethane and diethylzinc gives rise to cis-cyclopropane derivative (II) as a mixture of diastereoisomers.Subsequent hydrolysis of ester (II) with LiOH in aqueous dioxane provides the desired carboxylic acid.(1,2)
📌 参考资料/链接：
参考文献标题:Carboxylic acid cpd.having cyclopropane ring
文献作者:Tanaka,A.; Nishizaki,T.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:EP 1343746; WO 0250013
📄 详细内容
合成路线:Cyclopropanation of linoleic acid methyl ester (I) employing diiodomethane and diethylzinc gives rise to cis-cyclopropane derivative (II) as a mixture of diastereoisomers.Subsequent hydrolysis of ester (II) with LiOH in aqueous dioxane provides the desired carboxylic acid.(1,2)
参考文献标题:The newly synthesized linoleic acid derivative FR236924 induces a long-lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors
文献作者:Tanaka,A.; Nishizaki,T.
参考来源:Bioorg Med Chem Lett 2003,13(6),1037
产品链接: CAS No. 28399-31-7››