TMB-8
8-(二乙基氨基)辛基3,4,5-三甲氧基苯甲酸酯Chemical Name: 8-(N,N-Diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride; 3,4,5-Trimethoxybenzoic acid 8-(diethylamino)octyl ester hydrochloride
CAS No. 57818-92-5 (free base)
项目整合开发状态: Preclinical
项目研究机构: Aldrich (Originator)
合成路线:TMBN's have been synthesized by the method of Sastry and Lasslo by dissolving 0.05 moles of 3,4,5-trimethoxybenzoic acid (I) in 300 ml of dry benzene,to which 100 ml benzene containing 0.05 moles n-(N,N-dimethylamino) (CH2)nOH (II) was added dropwise with constant stirring.The temperature was maintained at 29-34 C.The reaction mixture was agitated for 2 additional hours at room temperature,then refluxed for 2 hours on steam bath.The product was recrystallized from benzene or from a mixture of ether and benzene.TMB-8 is considered more difficult to synthesize than TMB-6.
📌 参考资料/链接：
参考文献标题:TMB-8
文献作者:Murer,E.H.
参考来源:Drugs Fut 1983,8(11),940
📄 详细内容
合成路线:TMBN's have been synthesized by the method of Sastry and Lasslo by dissolving 0.05 moles of 3,4,5-trimethoxybenzoic acid (I) in 300 ml of dry benzene,to which 100 ml benzene containing 0.05 moles n-(N,N-dimethylamino) (CH2)nOH (II) was added dropwise with constant stirring.The temperature was maintained at 29-34 C.The reaction mixture was agitated for 2 additional hours at room temperature,then refluxed for 2 hours on steam bath.The product was recrystallized from benzene or from a mixture of ether and benzene.TMB-8 is considered more difficult to synthesize than TMB-6.
参考文献标题:Aliphatic reserpine analogs
文献作者:Lasslo,A.; Sastry,B.V.R.
参考来源:J Org Chem 1958,231577-78
产品链接: CAS No. 57818-92-5››