合成路线:By cyclocondensation of isatine (V) with cyclohexanone (II) and aqueous concentrated NH3 at 150 C in a pressure vessel to acridine-9-carboxamide (VI),followed by a Hoffman degradation with Br2 and sodium methoxide in methanol
合成路线:This compound can be prepared by two different methods:1) By cyclocondensation of p-anisidine (I) with 2-oxocyclohexanecarboxylate (II) to 7-methoxy-1,2,3,4-tetrahydroacridone (III),which by treatment with refluxing POCl3 is converted to 9-chloro-7-methoxy-1,2,3,4-tetrahydroacridine (IV).This compound is converted to final product by treatment with NH3 in refluxing p-cresol.2) By cyclocondensation of 5-methoxyisatin (V) and cyclohexanone (VI) in concentrated aqueous ammonia at 150 C to 7-methoxy-1,2,3,4-tetrahydroacridine-9-carboxamide (VII),followed by a Hoffman degradation with potassium hypobromite.
参考文献标题:Analogues of 9-amino-1,2,3,4-tetrahydroacridine
文献作者:Bielavsky,J.
参考来源:Coll Czech Chem Commun 1977,422802-7
合成路线:This compound can be prepared by two different methods:1) By cyclocondensation of p-anisidine (I) with 2-oxocyclohexanecarboxylate (II) to 7-methoxy-1,2,3,4-tetrahydroacridone (III),which by treatment with refluxing POCl3 is converted to 9-chloro-7-methoxy-1,2,3,4-tetrahydroacridine (IV).This compound is converted to final product by treatment with NH3 in refluxing p-cresol.2) By cyclocondensation of 5-methoxyisatin (V) and cyclohexanone (VI) in concentrated aqueous ammonia at 150 C to 7-methoxy-1,2,3,4-tetrahydroacridine-9-carboxamide (VII),followed by a Hoffman degradation with potassium hypobromite.
参考文献标题:7-MEOTA
文献作者:Dejmek,L.
参考来源:Drugs Fut 1990,15(2),126
产品链接: CAS No. 5778-80-3››