Tifenazoxide, NN-414

6-氯-3-((1-甲基环丙基)氨基)-4H-噻吩并(3,2-e)-1,2,4-噻二嗪 1,1-二氧化物Chemical Name: 6-Chloro-3-(1-methylcyclopropylamino)-4H-thieno[3,2-e][1,2,4]thiadiazine-1,1-dioxide
CAS No. 279215-43-9
项目整合开发状态: Discontinued
项目研究机构: Novo Nordisk (Originator)
合成路线:The known dichloro thienothiadiazine (I) was condensed with 1-methylcyclopropylamine (II) to produce the target 3-amino thienothiadiazine.
📌 参考资料/链接:
参考文献标题:Fused 1,2,4-thiadiazine derivs.,their preparation and use
文献作者:Hansen,J.B.; Nielsen,F.E.(Novo Nordisk A/S)
参考来源:EP 1140945; US 6329367; WO 0037474

📄 详细内容


合成路线:By cyclization of O-methylvalerolactam (I) with 3-(4-o-tolyl-1-piperazinyl) propionic acid hydrazide (II) in refluxing xylene,followed by a treatment with ethanolic HCl.

合成路线:Acylation of (1-methylcyclopropyl)guanidine (IV) with 3-bromo-5-chlorothiophene-2-sulfonyl chloride (III) under Schotten-Baumann conditions afforded the sulfonyl guanidine (V).This was cyclized to the desired thienothiadiazine upon treatment with Cs2CO3 and Cu2O in boiling butanol.

合成路线:In a closely related method,guanidine (IV) was sulfonylated with 3,5-dichlorothiophene-2-sulfonyl chloride (VI),and the resultant sulfonylguanidine (VII) was then cyclized in the presence of Cs2CO3 and Cu2O as above.

合成路线:In a different method,(1-methylcyclopropyl)guanidine (I) is acylated by 3-bromo-5-chlorothiophene-2-sulfonyl chloride (II) to produce the sulfonyl guanidine (III).Intramolecular cyclization of (III) in the presence of Cu2O and Cs2CO3 leads to the title thienothiadiazine derivative.Similarly,acylation of guanidine (I) with 3,5-dichlorothiophene-2-sulfonyl chloride (IV) provides sulfonyl guanidine (V),which is then cyclized in the presence of Cu2O and Cs2CO3.

合成路线:In an alternative method,sulfonylation of N-isopropylguanidine (V) with 2,5-dichlorothiophene-3-sulfonyl chloride (IV) produced the sulfonyl guanidine (VI).This was then cyclized to the title compound by treatment with copper bronze and potassium carbonate in boiling DMF.

参考文献标题:Novel process
文献作者:Nielsen,F.E.; Ebdrup,S.(Novo Nordisk A/S)
参考来源:WO 0102410


合成路线:In a closely related method,guanidine (IV) was sulfonylated with 3,5-dichlorothiophene-2-sulfonyl chloride (VI),and the resultant sulfonylguanidine (VII) was then cyclized in the presence of Cs2CO3 and Cu2O as above.

合成路线:A related strategy was based in the lithiation of either sulfonylguanidines (V) or (VII) with BuLi,followed by treatment with trimethyl borate to afford the intermediate methyl boronate (VIII) which upon acidic quenching led to the boronic acid (IX).Cyclization of (IX) to the title bicyclic derivative was then accomplished by treatment with cupric acetate in pyridine.
参考文献标题:A new process for preparing fused 1,2,4-thiadiazine derivs.
文献作者:Nielsen,F.E.; Kornoe,H.T.; Rasmussen,K.G.(Novo Nordisk A/S)
参考来源:WO 0250085


产品链接: CAS No. 279215-43-9››