BW-683C
6-氯-2-(4-氯苯基)色满Chemical Name: 6-Chloro-2-(4-chlorophenyl)-3,4-dihydro-2H-1-benzopyran; 4',6-Dichloroflavan
CAS No. 73110-56-2
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator)
合成路线:The condensation of 2-hydroxychloroacetophenone (I) with 4-chlorobenzaldehyde (II) by means of KOH in ethanol - water gives 4,5'-dichloro-2'-hydroxychalcone (III),which is cyclized by treatment with polyphosphoric acid (PPA) in reftuxing 2-methoxyethanol yielding 4',6-dichloroflavan (IV).Finally,this compound is reduced with Zn-Hg in acetic acid-hydrochloric acid.
📌 参考资料/链接：
参考文献标题:Flavans,process for their preparation and pharmaceutical compsns.containing them
文献作者:Batchelor,J.F.; Bauer,D.J.; Hodson,H.F.; Selway,J.W.T.; Young,D.A.B.(Glaxo Wellcome plc)
参考来源:EP 0004579
📄 详细内容
合成路线:The condensation of 2-hydroxychloroacetophenone (I) with 4-chlorobenzaldehyde (II) by means of KOH in ethanol - water gives 4,5'-dichloro-2'-hydroxychalcone (III),which is cyclized by treatment with polyphosphoric acid (PPA) in reftuxing 2-methoxyethanol yielding 4',6-dichloroflavan (IV).Finally,this compound is reduced with Zn-Hg in acetic acid-hydrochloric acid.
参考文献标题:BW-683C
文献作者:Serradell,M.N.; Castar,J.; Hopkins,S.J.; Blancafort,P.
参考来源:Drugs Fut 1982,7(8),542
产品链接: CAS No. 73110-56-2››