CD-3127, LG-268, LG-100268

6-[1-(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)环丙基]-3-吡啶羧酸Chemical Name: 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]pyridine-3-carboxylic acid
CAS No. 153559-76-3
项目整合开发状态: Preclinical
项目研究机构: Ligand (Originator)
合成路线:In a different strategy,electrophilic bromination of tetrahydronaphthalene (I) with Br2 and AlCl3 produces aryl bromide (II).Metalation of (II) with butyllithium,followed by reaction with triisopropyl borate,gives rise to the boronic acid (III).Treatment of methyl 4-acetylbenzoate (IV) with trifluoromethanesulfonic anhydride leads to the vinyl triflate (V).Then,Suzuki coupling of boronic acid (III) with vinyl triflate (V) furnishes the gem-diarylethylene derivative (VI).Finally,basic hydrolysis of the methyl ester group of (VI) provides the title carboxylic acid

合成路线:The Friedel Crafts condensation of 2,5-dichloro-2,2,5,5-tetramethylhexane (I) with toluene (II) by means of AlCl3 gives 1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphthalene (III),which is submitted to a new condensation with the pyridine-2-carbonyl chloride (IV) by means of AlCl3 in dichloromethane to yield the diaryl ketone (V).The reaction of (V) with methyltriphenylphosphonium bromide (VI) and NaNH2 affords the 1,1-diarylethylene (VII),which is treated with Et2Zn and Cl-CH2-I in dichloromethane to provide the 1,1-diarylcyclopropane (VIII).Finally,the ester group of (VIII) is hydrolyzed with KOH in methanol/water to yield the target carboxylic acid.

合成路线:Friedel-Crafts condensation of 2,5-dichloro-2,5-dimethylhexane (I) with toluene (II) in the presence of AlCl3 or FeCl3 afforded the tetrahydronaphthalene (III).Subsequent acylation of (III) with monomethyl terephthalic acid chloride (IV) provided keto ester (V),which was hydrolyzed to keto acid (VI) with methanolic KOH.Condensation of (VI) with hydroxylamine hydrochloride gave the corresponding oxime as a mixture of geometric isomers.The required Z isomer was then isolated by recrystallization from chloroform/hexane.