TNK-6123

6-(环己基磺酰)-1-(乙氧基甲基)-5-异丙基-1,3-二氢嘧啶-2,4-二酮Chemical Name: 6-(Cyclohexylsulfanyl)-1-(ethoxymethyl)-5-isopropyl-1,3-dihydropyrimidine-2,4-dione; 6-(Cyclohexylsulfanyl)-1-(ethoxymethyl)-5-isopropyluracil
CAS No. 251481-69-3
项目整合开发状态: Biological Testing
项目研究机构: Kagoshima University (Originator), Showa University (Originator), University of Oxford (Originator)
合成路线:The title compound was synthesized by sulfenylation of 1-(ethoxymethyl)-5-isopropyluracil (I) with dicyclohexyl disulfide (II) in the presence of lithium 2,2,6,6-tetramethylpiperidine in cold THF.
📌 参考资料/链接:
参考文献标题:Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants
文献作者:Hopkins,A.L.; Ren,J.; Tanaka,H.; Baba,M.; Okamoto,M.; Stuart,D.I.; Stammers,D.K.
参考来源:J Med Chem 1999,42(22),4500

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产品链接: CAS No. 251481-69-3››