Egualen sodium, Azuletil sodium, KT1-32, KTI-32, Azuloxa

乙呱仑 Chemical Name: 3-Ethyl-7-isopropylazulene-1-sulfonic acid sodium salt
CAS No. 97683-31-3, 99287-30-6 (free acid)
项目整合开发状态: Launched-2001
项目研究机构: Kotobuki (Originator)
合成路线:The synthesis of [14C]-labeled KT1-32 has been reported:The acylation of 7-isopropylazulene-1-carboxylic acid ethyl ester (I) with 1-[14C]-acetyl chloride-SnCl4 in dichloromethane gives the corresponding 3-acetyl derivative (II),which is reduced with sodium cyanoborohydride and boron trifluoride in ether to the 3-ethyl derivative (III).The decarboxylation of (III) with polyphosphoric acid at 100 C affords 1-[14C]-ethyl-5-isopropylazulene (IV),which is finally sulfonated with the pyridine-SO3 complex in refluxing benzene.