Urapidil, B-66256, Eupressyl, Ebrantil
乌拉地尔Chemical Name: 6-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyluracil; 6-[3-[4-(2-Methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
CAS No. 34661-75-1
项目整合开发状态: Launched-1981
项目研究机构: Altana Pharma (Originator), Kaken (Licensee)
合成路线:Compound can be prepared in two different ways:1) By condensation of o-methoxyphenylpiperazine carbonate (I) with 1,3-dimethyl-4-(3-chloropropylamino)uracil (II) in refluxing water.2) By condensation of N-(o-methoxyphenyl)-N'-(3-aminopropyl)piperazine (III) with 1,3-dimethyl-4-chlorouracil (IV) in refluxing triethylamine.
📌 参考资料/链接：
参考文献标题:Urapidil
文献作者:Castar,J.; Garc韆-Rafanell,J.
参考来源:Drugs Fut 1978,3(5),397
📄 详细内容
合成路线:Compound can be prepared in two different ways:1) By condensation of o-methoxyphenylpiperazine carbonate (I) with 1,3-dimethyl-4-(3-chloropropylamino)uracil (II) in refluxing water.2) By condensation of N-(o-methoxyphenyl)-N'-(3-aminopropyl)piperazine (III) with 1,3-dimethyl-4-chlorouracil (IV) in refluxing triethylamine.
参考文献标题:Aryl-substituted piperazinyl-alkylamino-uracils,-uracil ethers and -uracil thioethers and method for their production
文献作者:Pruesse,W.; et al.
参考来源:FR 2073300; GB 1309324; US 3957786; US 4067982
产品链接: CAS No. 34661-75-1››