合成路线:The reaction of 2-chloroethyl vinyl ether (III) with bromine gives 1,2-dibromo-2-[(2-chloro)ethoxy]ethane (IV) which reacts with the magnesian derivative (II) [obtained from (3-trifluoromethyl)bromobenzene (I) and magnesium in anhydrous ether] to give 2-[(3-trifluoromethyl)phenyl]-2-[(2-chloro)ethoxy]-1-bromoethane (V).The compound (V) is heated in an autoclave at 100 C with isopropylamine (VI) in toluene.
参考文献标题:Tetrahydro-1,4-oxazines.I.Nex synthesis method and a study of their interaction with tryptaminergic D receptors
文献作者:Busch,N.; et al.
参考来源:Eur J Med Chem - Chim Ther 1976,11(3),201-7
合成路线:The reaction of 2-chloroethyl vinyl ether (III) with bromine gives 1,2-dibromo-2-[(2-chloro)ethoxy]ethane (IV) which reacts with the magnesian derivative (II) [obtained from (3-trifluoromethyl)bromobenzene (I) and magnesium in anhydrous ether] to give 2-[(3-trifluoromethyl)phenyl]-2-[(2-chloro)ethoxy]-1-bromoethane (V).The compound (V) is heated in an autoclave at 100 C with isopropylamine (VI) in toluene.
参考文献标题:Oxaflozane
文献作者:Serradell,M.N.; Blancafort,P.
参考来源:Drugs Fut 1978,3(9),667
产品链接: CAS No. 26629-87-8››