Triflusal, UR-1501, Tecnosal, Disgren
三氟醋柳酸Chemical Name: 2-Acetoxy-4-(trifluoromethyl)benzoic acid; 4-(Trifluoromethyl)salicylic acid acetate
CAS No. 322-79-2
项目整合开发状态: Launched-1981
项目研究机构: Uriach (Originator), Pfizer (Not Determined)
合成路线:Trifluoromethylphenol (I) is converted into 2-hydroxy-4-trifluoromethylbenzoic acid (II) by treatment with potassium carbonate and carbon dioxide under pressure (Kolbe-Schmitt reaction).(II) is then converted with a suitable acetylating agent in the 2-acetoxy-4-trifluoromethylbenzoic acid (III).
📌 参考资料/链接：
参考文献标题:Triflusal
文献作者:Mar韓,A.; Francia,E.; Garc韆 Rafanell,J.
参考来源:Drugs Fut 1978,3(3),225
📄 详细内容
合成路线:Trifluoromethylphenol (I) is converted into 2-hydroxy-4-trifluoromethylbenzoic acid (II) by treatment with potassium carbonate and carbon dioxide under pressure (Kolbe-Schmitt reaction).(II) is then converted with a suitable acetylating agent in the 2-acetoxy-4-trifluoromethylbenzoic acid (III).
参考文献标题:4-Trifluoromethylbenzoic acid derivatives as thromboembolic agents
文献作者:Barra,E.F.; Mar韓,A.
参考来源:DE 2641556; ES 459855; FR 2354335; GB 1588633; JP 52156831; US 4096252
产品链接: CAS No. 322-79-2››