SDZ-64412

5-[4-[2-(3,4,5-三甲氧基苯基)乙基]苯基]-2,3-二氢咪唑并[2,1-a]异喹啉盐酸盐Chemical Name: 5-[4-[2-(3,4,5-Trimethoxyphenyl)ethyl]phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline hydrochloride
CAS No. 115622-31-6
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:The reaction of 2-(2-methylphenyl)-4,5-dihydro-1H-imidazole (I) with n-BuLi in tetramethylethylenediamine gives the dilithium salt (II),which is cyclized with 4-(3,4,5-trimethoxybenzyloxy)benzoic acid methyl ester (III),yielding imidazoquinoline (IV).Finally,this compound is dehydrated in refluxing acetic acid or in refluxing toluene catalyzed by p-toluenesulfonic acid.

合成路线:The reaction of 2-(2-methylphenyl)-4,5-dihydro-1H-imidazole (I) with n-BuLi in tetramethylethylenediamine gives the dilithium salt (II),which is cyclized with 4-[2-(3,4,5-trimethoxyphenyl)ethyl]benzoic acid methyl ester (III),yielding imidazoquinoline (IV).Finally,this compound is dehydrated in refluxing acetic acid or in refluxing toluene catalyzed by p-toluenesulfonic acid.