Trifluoropentoxypicolinic acid, ND-186 H-5
5-(5,5,5-三氟戊氧基)吡啶-2-羧酸Chemical Name: 5-[(5,5,5-Trifluoropentyl)oxy]-2-pyridinecarboxylic acid; 5-(5,5,5-Trifluoropentoxy)picolinic acid
CAS No. 72133-44-9, 72133-65-4 (Ca salt)
项目整合开发状态: Biological Testing
项目研究机构: Meiji Seika (Originator)
合成路线:The condensation of 5-hydroxy-2-hydroxymethylpyridine (I) with 1,1,1-trifluoro-5-bromopentane (II) by means of KOH in hot DMF gives 5-(5,5,5 trifluoropentyloxy)-2-hydroxymethylpyridine (III),which is then oxidized with KMnO4 in butanol water.
📌 参考资料/链接：
参考文献标题:5-Alkoxypicolinic acid ester,its preparation,and hypotensive agent containing the same
文献作者:Hachisu,M.; Inouye,S.; Sezaki,M.; Shimomura,K.; Koeda,T.; Tsuruoka,T.; Niida,T.; Shibata,U.; Miyamoto,M.; Mizutani,K.; Sekizawa,Y.(Meiji Seika Kaisha,Ltd.)
参考来源:BE 875070; JP 1979125680
📄 详细内容
合成路线:The condensation of 5-hydroxy-2-hydroxymethylpyridine (I) with 1,1,1-trifluoro-5-bromopentane (II) by means of KOH in hot DMF gives 5-(5,5,5 trifluoropentyloxy)-2-hydroxymethylpyridine (III),which is then oxidized with KMnO4 in butanol water.
参考文献标题:5-Substituted picolinic acid derivatives and an anti-hypertensive composition containing the same
文献作者:Seikizawa,Y.; et al.(Meiji Seika Kaisha,Ltd.)
参考来源:US 4229448
合成路线:The condensation of 5-hydroxy-2-hydroxymethylpyridine (I) with 1,1,1-trifluoro-5-bromopentane (II) by means of KOH in hot DMF gives 5-(5,5,5 trifluoropentyloxy)-2-hydroxymethylpyridine (III),which is then oxidized with KMnO4 in butanol water.
参考文献标题:Trifluoropentoxypicolinic acid
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1985,10(7),573
产品链接: CAS No. 72133-44-9››