SLV-319
5-(4-氯苯基)-N-(4-氯苯基)磺酰基-N'-甲基-4-苯基-3,4-二氢吡唑-2-甲脒Chemical Name: 4-Chloro-N-[1-[3-(4-chlorophenyl)-4(S)-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1-(methylamino)methylidene]benzenesulfonamide; 3-(4-Chlorophenyl)-N2-(4-chlorophenylsulfonyl)-N1-methyl-4(S)-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamidine
CAS No. 362519-49-1 (racemate)
项目整合开发状态: Phase I
项目研究机构: Solvay (Originator), Bristol-Myers Squibb (Licensee)
合成路线:Condensation of dihydropyrazole (I) with the sulfonyl carbamate (II) in the presence of pyridine gives rise to the 1-acyl dihydropyrazole (III).Subsequent chlorination of (III) using PCl5 in refluxing chlorobenzene affords the imidoyl chloride (IV).This is finally condensed with methylamine in CH2Cl2 to furnish the title compound.
📌 参考资料/链接：
参考文献标题:4,5-Dihydro-1H-pyrazole derivs.having CB 1-antagonistic activity
文献作者:Kruse,C.G.; Tulp,M.T.M.; Lange,J.H.M.; Tipker,J.; Van Vliet,B.J.(Solvay Pharmaceuticals BV)
参考来源:EP 1268435; US 2001053788; US 6476060; WO 0170700
📄 详细内容
合成路线:Condensation of dihydropyrazole (I) with the sulfonyl carbamate (II) in the presence of pyridine gives rise to the 1-acyl dihydropyrazole (III).Subsequent chlorination of (III) using PCl5 in refluxing chlorobenzene affords the imidoyl chloride (IV).This is finally condensed with methylamine in CH2Cl2 to furnish the title compound.
参考文献标题:4,5-Dihydro-1H-pyrazole derivs.having CB1-antagonistic activity
文献作者:Kruse,C.G.; Lange,J.H.M.; Tipker,J.; Hoogendoorn,J.(Solvay Pharmaceuticals BV)
参考来源:WO 0276949
产品链接: CAS No. 362519-49-1››