合成路线:By condensation of fumagillol [(3R,4S,5S,6R)-4-(1,2-epoxy-1,5-dimethyl4-hexenyl)-6-hydroxy-5-methoxy-1-oxaspiro[2.5]octane] (I) with chloroacetylisocyanate (II) by means of dimethylaminopyridine (DMAP) in dichloromethane.
参考文献标题:Cyclohexanol derivs.,production and use thereof
文献作者:Kishimoto,S.; Marui,S.; Fujita,T.(Takeda Chemical Industries,Ltd.)
参考来源:EP 0415294; JP 1991279376; US 5180735
合成路线:By condensation of fumagillol [(3R,4S,5S,6R)-4-(1,2-epoxy-1,5-dimethyl4-hexenyl)-6-hydroxy-5-methoxy-1-oxaspiro[2.5]octane] (I) with chloroacetylisocyanate (II) by means of dimethylaminopyridine (DMAP) in dichloromethane.
参考文献标题:Chemical modification of fumagillin.I.6-O-Acyl,6-O-sulfonyl,6-O-alkyl,and 6-O-(N-substituted-carbamoyl)fumagillols
文献作者:Marui,S.; Itoh,F.; Kozai,Y.; Sudo,K.; Kishimoto,S.
参考来源:Chem Pharm Bull 1992,40(1),96-101
合成路线:By condensation of fumagillol [(3R,4S,5S,6R)-4-(1,2-epoxy-1,5-dimethyl4-hexenyl)-6-hydroxy-5-methoxy-1-oxaspiro[2.5]octane] (I) with chloroacetylisocyanate (II) by means of dimethylaminopyridine (DMAP) in dichloromethane.
参考文献标题:AGM-1470
文献作者:Mealy,N.; Prous,J.; Castar,J.
参考来源:Drugs Fut 1994,19(11),981
合成路线:By condensation of fumagillol [(3R,4S,5S,6R)-4-(1,2-epoxy-1,5-dimethyl4-hexenyl)-6-hydroxy-5-methoxy-1-oxaspiro[2.5]octane] (I) with chloroacetylisocyanate (II) by means of dimethylaminopyridine (DMAP) in dichloromethane.
参考文献标题:Angiogenesis inhibitory agent
文献作者:Fujita,T.; Kanamaru,T.; Folkman,M.; Ingber,D.(Children's Med.Cent.Corp.; Takeda Chemical Industries,Ltd.)
参考来源:EP 0357061
产品链接: CAS No. 129298-91-5››