(?-PPG

4-磷酰基苯甘氨酸Chemical Name: (?-2-Amino-2-(4-phosphonophenyl)acetic acid
CAS No. 120667-15-4, 120667-18-7 (hydrochloride)
项目整合开发状态: Preclinical
项目研究机构: Merck & Co. (Originator), Novartis (Originator)
合成路线:Condensation of alpha-hydroxyhippuric acid (II) with bromobenzene (I) in methanesulfonic acid afforded the phenylglycine derivative (III).Further incorporation of the phosphonic acid was effected by palladium-catalyzed displacement of the bromide by diethyl phosphite to give (IV).Finally,acid hydrolysis of the benzamide and phosphite ester groups furnished the title compound.