MS-31-038
4-喹喹碱羧酰胺,N-(氨基亚氨基甲基)-8-(2-甲氧基乙氧基)-2-苯基-Chemical Name: N1-[8-(2-Methoxyethoxy)-2-phenylquinolin-4-ylcarbonyl]guanidine bis(methanesulfonate)
CAS No. 181048-36-2 (free base), 181049-21-8 (monomethanesulfonate)
项目整合开发状态: Preclinical
项目研究机构: Mitsui Chemicals (Originator)
合成路线:Quinoline (IV) was prepared by condensation of 3,5-dimethoxyaniline (I),pyruvic acid (II) and o-tolualdehyde (III) in refluxing EtOH.After activation of (IV) as the acid chloride (V) by means of SOCl2 in benzene,its condensation with guanidine (VI) in DMF yielded the corresponding acyl guanidine.
合成路线:Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I),pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH.After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF,its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.
📌 参考资料/链接：
参考文献标题:Quinoline-4-carbonylguanidine derivates,process for producing the same and pharmaceutical compsns.containing the cpds.
文献作者:Fujiwara,J.; Mori,H.; Yamashita,H.; Kitamori,T.; Hosoya,J.; Banno,H.(Mitsui Chemicals,Inc.)
参考来源:EP 0726254; JP 1996277269; US 5627193
📄 详细内容
合成路线:Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I),pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH.After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF,its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.
参考文献标题:MS-31-038
文献作者:Kitamori,T.; Hosoya,J.; Mori,H.; Banno,H.; Kibayashi,K.; Yamashita,H.; Fujiwara,J.
参考来源:Drugs Fut 1999,24(12),1306
合成路线:Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I),pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH.After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF,its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.
参考文献标题:Ueber alpha-alkylcinchoninsauren
文献作者:Doebner,O.
参考来源:Ber 1887,20277-80
合成路线:Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I),pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH.After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF,its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.
参考文献标题:Chinolinederivate aus isatinsaure
文献作者:Pfitzinger,W.
参考来源:J Prakt Chem 1886,33100
产品链接: CAS No. 181048-36-2›› 产品链接: CAS No.181049-21-8››