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项目整合精选>>>Nabutan hyrochloride(former USAN), Nabitan hydrochloride(Prop INNM, USAN), SP-106, Abbott-4056, NIB, BPP
Nabutan hyrochloride(former USAN), Nabitan hydrochloride(Prop INNM, USAN), SP-106, Abbott-4056, NIB, BPP
4-哌啶丁酸[8-(1,2-二甲基庚基)-5,5-二甲基-2-炔丙基-3,4-二氢-1H-苯并吡喃o[4,3-c]吡啶-10-基]酯盐酸盐 大麻坦 Chemical Name: (?-8-(3-Methyl-2-octyl)-1,3,4,5-tetrahydro-5,5-dimethyl-2-(2-propynyl)-2H-[1]benzopyrano[4,3-c]pyridin-10-yl 1-piperidinebutyrate hydrochloride; 1-Piperidinebutanoic acid 8-(1,2-dimethylheptyl)-1,3,4,5-tetrahydro-5,5-dimethyl-2-(2-propynyl)-2H-[1]benzopyrano[4,3-c]pyridin-10-yl ester hydrochloride; 5,5-Dimethyl-8-(3-methyl-2-octyl)-10-[4-(1-piperidyl)butyryloxy]-2-(2-propynyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine hydrochloride
CAS No. 49637-08-3, 66556-74-9 (free base)
项目整合开发状态: Phase II
项目研究机构: Abbott (Originator), Sisa (Originator)
合成路线:Ethyl 4-bromobutyrate (I) is condensed with piperidine (II) in refluxing benzene to give ethyl 4-(1-piperidyl)butyrate (III),which is hydrolyzed with refluxing aqueous HCl to 4-(1-piperidyl)butyric acid (IV) .Finally,this acid is esterified with 5,5-dimethyl-8-(3-methyl-2-octyl)-10-hydroxy-2-(2-propynyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine (V) by means of dicyclohexylcarbodiimide (A) in methylene chloride.
📌 参考资料/链接：
参考文献标题:Nabitan Hydrochloride
文献作者:Castar,J.; Paton,D.M.
参考来源:Drugs Fut 1980,5(9),439
📄 详细内容
合成路线:Ethyl 4-bromobutyrate (I) is condensed with piperidine (II) in refluxing benzene to give ethyl 4-(1-piperidyl)butyrate (III),which is hydrolyzed with refluxing aqueous HCl to 4-(1-piperidyl)butyric acid (IV) .Finally,this acid is esterified with 5,5-dimethyl-8-(3-methyl-2-octyl)-10-hydroxy-2-(2-propynyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine (V) by means of dicyclohexylcarbodiimide (A) in methylene chloride.
参考文献标题:Drugs derived from cannabinoids.2.Basic esters of nitrogen and carboxylic analogs
文献作者:Razdan,R.K.; Terris,B.Z.; Pars,H.G.; Plotnikoff,N.P.; Dodge,P.W.; Dren,A.T.; Kyncl,J.; Somani,P.
参考来源:J Med Chem 1976,19(4),454-461
合成路线:Ethyl 4-bromobutyrate (I) is condensed with piperidine (II) in refluxing benzene to give ethyl 4-(1-piperidyl)butyrate (III),which is hydrolyzed with refluxing aqueous HCl to 4-(1-piperidyl)butyric acid (IV) .Finally,this acid is esterified with 5,5-dimethyl-8-(3-methyl-2-octyl)-10-hydroxy-2-(2-propynyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine (V) by means of dicyclohexylcarbodiimide (A) in methylene chloride.
参考文献标题:
文献作者:Dren,A.T.; Ebert,D.M.
参考来源:US 4025630
产品链接: CAS No. 49637-08-3›› 产品链接: CAS No.66556-74-9››