S-151276, S-15176
S-15176二富马酸盐盐 Chemical Name: 2,6-Di-tert-butyl-4-[3-[4-(2,3,4-trimethoxybenzyl)-1-piperazinyl]propylsulfanyl]phenol
CAS No. 148089-70-7, 148913-55-7 (fumarate)
项目整合开发状态: Preclinical
项目研究机构: Servier (Originator)
合成路线:The condensation between bromide (I) and piperazine (II) in refluxing acetonitrile provided the disubstituted piperazine (III).The acetate ester was then hydrolyzed by means of NaOH to yield the title compound.
📌 参考资料/链接：
参考文献标题:Trimetazidine derivs.,process for their preparation and pharmaceutical compsns.containing them
文献作者:Regnier,G.; Vilaine,J.-P.; Villeneuve,N.; Bidouard,J.-P.; Iliou,J.-P.; Lenaers,A.(ADIR et Cie.)
参考来源:EP 0533579; FR 2681324; JP 1993194451; US 5283246