Centbucridine, CDRI-64/124
丁吖卡因 Chemical Name: N-(Butylamino)-1,2,3,4-tetrahydroacridine hydrochloride
CAS No. 34811-20-6, 316-15-4 (free base)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:Anthranitic acid (I) is reacted with cyclohexanone (II) to give 5-hydroxy-1,2,3,4-tetrahydroacridine (III).The hydroxy compound (III) is then reacted with phosphorous oxychloride to give 5-chloro-1,2,3,4-tetrahydroacridine (IV).Aminolysis of (IV) with n-butylamine affords centbucridine.
📌 参考资料/链接：
参考文献标题:Compounds acting on the central nervous system.IV.4-substituted 2,3-polymethylenequinolines
文献作者:Patnaik,G.K.; Vohra,M.M.; Bindra,J.S.; Garg,C.P.; Anand,N.
参考来源:J Med Chem 1966,9(4),483
📄 详细内容
合成路线:Anthranitic acid (I) is reacted with cyclohexanone (II) to give 5-hydroxy-1,2,3,4-tetrahydroacridine (III).The hydroxy compound (III) is then reacted with phosphorous oxychloride to give 5-chloro-1,2,3,4-tetrahydroacridine (IV).Aminolysis of (IV) with n-butylamine affords centbucridine.
参考文献标题:Studies in 4-substituted 2,3-polymethylene quinolines
文献作者:Patnaik,G.K.; et al.
参考来源:CNS Drugs Ed.G.S.Sidhu,CSI,New Delhi
合成路线:Anthranitic acid (I) is reacted with cyclohexanone (II) to give 5-hydroxy-1,2,3,4-tetrahydroacridine (III).The hydroxy compound (III) is then reacted with phosphorous oxychloride to give 5-chloro-1,2,3,4-tetrahydroacridine (IV).Aminolysis of (IV) with n-butylamine affords centbucridine.
参考文献标题:Centbucridine
文献作者:Arya,V.P.
参考来源:Drugs Fut 1980,5(6),281
产品链接: CAS No.316-15-4››