SM-8849
4-[1-(3-氟-4-苯基苯基)乙基]-N-甲基-1,3-噻唑-2-胺Chemical Name: 4-[1-(2-Fluorobiphenyl-4-yl)ethyl]-N-methylthiazole-2-amine; 4-[1-(2-Fluorobiphenyl-4-yl)ethyl]-2-(methylamino)thiazole
CAS No. 113759-19-6
项目整合开发状态: Phase II
项目研究机构: Sumitomo Pharmaceuticals (Originator)
合成路线:The reaction of 2-(2-fluorobiphenyl-4-yl)propionic acid (I) with thionyl chloride followed by treatment with tris (trimethylsilyloxy)ethylene gives 3-(2-fluorobiphenyl-4-yl)-1-hydroxy-2-butanone (II),which upon treatment with carbon tetrachloride and triphenylphosphine affords 1-chloro-3-(2-fluorobiphenyl-4-yl)-2-butanone (III).Finally,compound (III) is heated with N-methylthiourea in water.
📌 参考资料/链接：
参考文献标题:Aminazole derivatives and their production and use
文献作者:Ozato,Y.; Tamura,N.; Masumori,H.; Yamamoto,M.; Kojima,A.; Nishikakau,F.; Kimura,Y.(Sumitomo Pharmaceuticals Co.,Ltd.)
参考来源:EP 0248399; JP 1988152368; JP 1993247014; US 4914112; US 5066666; US 5180731
📄 详细内容
合成路线:The reaction of 2-(2-fluorobiphenyl-4-yl)propionic acid (I) with thionyl chloride followed by treatment with tris (trimethylsilyloxy)ethylene gives 3-(2-fluorobiphenyl-4-yl)-1-hydroxy-2-butanone (II),which upon treatment with carbon tetrachloride and triphenylphosphine affords 1-chloro-3-(2-fluorobiphenyl-4-yl)-2-butanone (III).Finally,compound (III) is heated with N-methylthiourea in water.
参考文献标题:SM-8849
文献作者:Prous,J.; Castar,J.; Graul,A.
参考来源:Drugs Fut 1994,19(4),347
产品链接: CAS No. 113759-19-6››