YM-17551
4-[[5-[(4-乙酰基-3-羟基-2-丙基苯基)甲基硫烷基]-1,3,4-噻二唑-2-基]硫烷基甲基]苯甲酸Chemical Name: 4-[5-(4-Acetyl-3-hydroxy-2-propylbenzylthio)-1,3,4-thiadiazol-2-ylthiomethyl]benzoic acid
CAS No. 107859-85-8
项目整合开发状态: Preclinical
项目研究机构: Yamanouchi (Originator)
合成路线:The reaction of 4-acetyl-3-hydroxy-2-propylbenzyl chloride (I) with 2,5-dimercapto-1,3,4-thiadiazole (II) in 2-butanone gives 2-[(4-acetyl-3-hydroxy-2-propylbenzyl)thio]-5-mercapto-1,3,4-thiadiazole (III),which is condensed with alpha-bromo-p-toluic acid (IV) in 2-butanone.
📌 参考资料/链接：
参考文献标题:(Substd.benzyl)thio heterocyclic cpds.having leukotriene-antagonist activity
文献作者:Mase,T.; Murase,K.; Tsuzuki,R.; Tomioka,K.; Hara,H.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:EP 0214732; US 4803211; US 4933348; US 5180730
📄 详细内容
合成路线:The reaction of 4-acetyl-3-hydroxy-2-propylbenzyl chloride (I) with 2,5-dimercapto-1,3,4-thiadiazole (II) in 2-butanone gives 2-[(4-acetyl-3-hydroxy-2-propylbenzyl)thio]-5-mercapto-1,3,4-thiadiazole (III),which is condensed with alpha-bromo-p-toluic acid (IV) in 2-butanone.
参考文献标题:YM-17551
文献作者:Yamada,T.; Tomioka,K.; Mase,T.
参考来源:Drugs Fut 1990,15(9),905
产品链接: CAS No. 107859-85-8››