NSC-724771, JS-K
4-[(Z)-(2,4-二硝基苯氧基)-氧偶氮基]-1-哌嗪羧酸乙酯Chemical Name: 4-(2,4-Dinitrophenoxy)-NNO-azoxy]piperazine-1-carboxylic acid ethyl ester
CAS No. 205432-12-8
项目整合开发状态: Preclinical
项目研究机构: National Cancer Institute (Originator), University of Utah (Originator), Veterans Administration Medical Center (Originator)
合成路线:Reaction of piperazine-1-carboxylic acid ethyl ester (I) with nitric oxide in the presence of NaOMe in a pressure bottle gives rise to the sodium piperazinyldiazenium diolate (II).This is finally condensed with 2,4-dinitrofluorobenzene (III) to produce the title compound.
📌 参考资料/链接：
参考文献标题:O2-Arylated or O2-glycosylated 1-substd.diazen-1-ium-1,2-diolates and O2-substd.1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
文献作者:Keefer,L.K.; Saavedra,J.E.; Srinivasan,A.; Rice,W.G.; Bogdan,C.; Ji,X.(US Department of Health & Human Services)
参考来源:JP 2002506421; WO 9813358
📄 详细内容
合成路线:Reaction of piperazine-1-carboxylic acid ethyl ester (I) with nitric oxide in the presence of NaOMe in a pressure bottle gives rise to the sodium piperazinyldiazenium diolate (II).This is finally condensed with 2,4-dinitrofluorobenzene (III) to produce the title compound.
参考文献标题:The secondary amine/nitric oxide complex ion R2N[N(O)NO](-) as nucleophile and leaving group in S(N)Ar reactions
文献作者:Saavedra,J.E.; Srinivasan,A.; Bonifant,C.L.; Chu,J.-Y.; Shanklin,A.P.; Flippen-Anderson,J.L.; Rice,W.G.; Turpin,J.A.; Davies,K.M.; Keefer,L.K.
参考来源:J Org Chem 2001,66(9),3090
产品链接: CAS No. 205432-12-8››