YM-511
4-[(4-溴苯基)甲基-(1,2,4-三唑-4-基)氨基]苯甲腈Chemical Name: 4-[N-(4-Bromobenzyl)-N-(4-cyanophenyl)amino]-4H-1,2,4-triazole; 4-[N-(4-Bromobenzyl)-N-(1,2,4-triazol-4-yl)amino]benzonitrile
CAS No. 148869-05-0
项目整合开发状态: Phase II
项目研究机构: Yamanouchi (Originator)
合成路线:The arylation of 1,2,4-triazol-4-amine (I) with 4-fluorobenzonitrile (II) by means of NaH in DMSO gives 4-(1,2,4-triazol-4-ylamino)benzonitrile (III),which is then condensed with 4-bromobenzyl bromide (III) by means of K2CO3 in acetonitrile.
📌 参考资料/链接：
参考文献标题:Triazolylated tertiary amine cpds.or salts thereof
文献作者:Okada,M.; Kawaminami,E.; Yoden,T.; Kudo,M.; Isomura,Y.(Yamanouchi Pharmaceutical Co.,Ltd.)
参考来源:EP 0641785; JP 1993505096; US 5674886; WO 9305027
📄 详细内容
合成路线:The arylation of 1,2,4-triazol-4-amine (I) with 4-fluorobenzonitrile (II) by means of NaH in DMSO gives 4-(1,2,4-triazol-4-ylamino)benzonitrile (III),which is then condensed with 4-bromobenzyl bromide (III) by means of K2CO3 in acetonitrile.
参考文献标题:YM-511
文献作者:Mealy,N.; Castar,J.
参考来源:Drugs Fut 1996,21(7),716
产品链接: CAS No. 148869-05-0››