SC-299
4-(2-甲基-4-苯基-1,3-恶唑-5-基)苯磺酰胺Chemical Name: 4-(2-Methyl-4-phenyloxazol-5-yl)benzenesulfonamide
CAS No. 93014-16-5
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:Chlorosulfonation of the commercially available 2-methyl-4,5-diphenyloxazole (I) with ClSO3H afforded sulfonyl chloride (II),which was then reacted with ammonium hydroxide to produce the title sulfonamide.
📌 参考资料/链接：
参考文献标题:Substd.oxazoles for the treatment of inflammation
文献作者:Talley,J.J.; Bertenshaw,S.; Rogier,D.J.Jr.; Graneto,M.; Brown,D.L.; Devadas,B.; Hwang-Fun,L.; Sikorski,J.A.(Pharmacia Corp.)
参考来源:EP 0825989; JP 1999509835; WO 9636617
📄 详细内容
合成路线:Chlorosulfonation of the commercially available 2-methyl-4,5-diphenyloxazole (I) with ClSO3H afforded sulfonyl chloride (II),which was then reacted with ammonium hydroxide to produce the title sulfonamide.
参考文献标题:4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)
文献作者:Talley,J.J.; Bertenshaw,S.R.; Brown,D.L.; Carter,J.S.; Graneto,M.J.; Koboldt,C.M.; Masferrer,J.L.; Norman,B.H.; Rogier,D.J.Jr.; Zwwifel,B.S.; Seibert,K.
参考来源:Med Res Rev 1999,9(3),199
产品链接: CAS No. 93014-16-5››