AA-10026, AA-10025, DDP-225, AA-10021, MCI-225
4-(2-氟苯基)-6-甲基-2-哌嗪-1-基噻吩并[2,3-d]嘧啶Chemical Name: 4-(2-Fluorophenyl)-6-methyl-2-piperazinothieno[2,3-d]pyrimidine hydrochloride hydrate
CAS No. 135991-48-9, 109348-38-1 (anhydrous), 99487-25-9 (anhydrous free base), 99487-26-0 (HCl salt monoH2O)
项目整合开发状态: Preclinical
项目研究机构: Mitsubishi Chemical (Originator), Mitsubishi Pharma (Originator), Arachnova (Not Determined), Dynogen Pharmaceuticals (Licensee), Taisho (Codevelopment)
合成路线:By condensation of 2-chloro-4-(2-fluorophenyl)-6-methylthieno[2,3-d]pyrimidine (I) with piperazine (II) in refluxing chloroform or ethanol.
📌 参考资料/链接：
参考文献标题:Thieno[2,3-d]pyrimidine derivs.And salts thereof
文献作者:Ninomiya,K.; Nitta,I.; Tobe,A.; Egawa,M.; Kikumoto,R.(Mitsubishi Chemical Corp.)
参考来源:EP 0150469; JP 1985146891
📄 详细内容
合成路线:By condensation of 2-chloro-4-(2-fluorophenyl)-6-methylthieno[2,3-d]pyrimidine (I) with piperazine (II) in refluxing chloroform or ethanol.
参考文献标题:Antidepressant and cerebral function improving agent
文献作者:Ninomiya,K.; Nitta,K.; Tobe,A.; Egawa,M.(Mitsubishi Chemical Corp.)
参考来源:JP 1987000427
合成路线:By condensation of 2-chloro-4-(2-fluorophenyl)-6-methylthieno[2,3-d]pyrimidine (I) with piperazine (II) in refluxing chloroform or ethanol.
参考文献标题:MCI-225
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1992,17(5),380
合成路线:By condensation of 2-chloro-4-(2-fluorophenyl)-6-methylthieno[2,3-d]pyrimidine (I) with piperazine (II) in refluxing chloroform or ethanol.
参考文献标题:Antidepressant and cerebral function improving agents
文献作者:Ninomiya,K.; Nitta,I.; Tobe,A.; Egawa,S.(Mitsubishi Chem.Ind.,Ltd.)
参考来源:JP 8700042
产品链接: CAS No. 135991-48-9››