NS-1, OCO-1112
4-(2-(4-异丙基苯并酰胺基)乙氧基)苯甲酸Chemical Name: 4-[2-(4-Isopropylbenzamido)ethoxy]benzoic acid
CAS No. 113079-40-6
项目整合开发状态: Phase II
项目研究机构: Nippon Shinyaku (Originator)
合成路线:The condensation of aziridine (I) with methyl 4-hydroxybenzoate (II) in refluxing chloroform gives methyl 4-(2-aminoethoxy)benzoate (III),which is acylated with 4-isopropylbenzoyl chloride by means of K2CO3 in chloroform yielding methyl 4-[2-(4-isopropylbenzamido)ethoxy]benzoate (IV).Finally,this compound is hydrolyzed with NaOH in refluxing water.
📌 参考资料/链接：
参考文献标题:Benzoic acid derivs
文献作者:Yoshikuni,Y.; Choaki,S.; Ozaki,T.; Yoshida,H.(Nippon Shinyaku Co.,Ltd.)
参考来源:CH 674204; DE 3718765; FR 2600059; GB 2191487; JP 1987292754; JP 1988159359; US 4831055
📄 详细内容
合成路线:The condensation of aziridine (I) with methyl 4-hydroxybenzoate (II) in refluxing chloroform gives methyl 4-(2-aminoethoxy)benzoate (III),which is acylated with 4-isopropylbenzoyl chloride by means of K2CO3 in chloroform yielding methyl 4-[2-(4-isopropylbenzamido)ethoxy]benzoate (IV).Finally,this compound is hydrolyzed with NaOH in refluxing water.
参考文献标题:NS-1
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1990,15(7),682
产品链接: CAS No. 113079-40-6››