AM-36

4-({4-[2-(4-氯苯基)-2-羟基乙基]-1-哌嗪基}甲基)-2,6-二(2-甲基-2-丙基)苯酚二盐酸盐Chemical Name: 4-[4-[2-(4-Chlorophenyl)-2-hydroxyethyl]piperazin-1-ylmethyl]-2,6-bis(tert-butyl)phenol
CAS No. 199467-52-2, 199467-53-3 (tartrate (1:2))
项目整合开发状态: Preclinical
项目研究机构: Amrad (Originator), DevCo (Licensee), Monash University (Codevelopment)
合成路线:Alkylation of ethyl 1-piperazinecarboxylate (I) with 2-bromo-4'-chloroacetophenone (II) afforded disubstituted piperazine (III).Further cleavage of the carbamate group of (III) in refluxing HCl produced piperazine (IV).Bromide (VII) was prepared by reduction of 3,5-di-tert-butyl-4-hydroxybenzaldehyde (V) with NaBH4,followed by treatment of the resulting alcohol (VI) with PBr3.Piperazine (IV) was then condensed with bromide (VII) to give adduct (VIII).Finally,ketone reduction using LiAlH4 furnished the title alcohol.