BIIL-260

4-((3-((4-(2-(4-(4-(4-(4-羟基苯)丙-2-基)苯氧基)甲基)苯甲基)氧)苯并咪酰胺Chemical Name: 4-[3-[4-[1-(4-Hydroxyphenyl)-1-methylethyl]phenoxy]methyl]benzyloxy]benzenecarboximidamide
CAS No. 204974-93-6
项目整合开发状态: Preclinical
项目研究机构: Boehringer Ingelheim (Originator)
合成路线:Nitrile (I) was converted to hydroxamic acid (II) upon treatment with hydroxylamine.Further hydrogenation in the presence of Raney-nickel provided amidine (III),which was finally condensed with ethyl chloroformate to yield the title compound.

合成路线:Nitrile (I) was converted to hydroxamic acid (II) upon treatment with hydroxylamine.Further hydrogenation in the presence of Raney-nickel provided the target amidine.