合成路线:Esterification of probucol (I) with succinic anhydride (II) in the presence of NaH afforded the title monosuccinate ester,which was separated from the unreacted probucol (I) and the corresponding disuccinate ester by column chromatography.Esterification of (I) was also reported in the presence of other bases,such as potassium tert-butoxide,KOH,DMAP and DABCO.
参考文献标题:Process for preparing probucol derivs.
文献作者:Jass,P.A.
参考来源:US 6323359
合成路线:Esterification of probucol (I) with succinic anhydride (II) in the presence of NaH afforded the title monosuccinate ester,which was separated from the unreacted probucol (I) and the corresponding disuccinate ester by column chromatography.Esterification of (I) was also reported in the presence of other bases,such as potassium tert-butoxide,KOH,DMAP and DABCO.
参考文献标题:Novel phenolic antioxidants as multifunctional inhibitors of inducible VCAM-1 expression for use in atherosclerosis
文献作者:Meng,C.Q.; Somers,P.K.; Rachita,C.L.; Holt,L.A.; Hoong,L.K.; Zehng,X.S.; Simpson,J.E.; Hill,R.R.; Olliff,L.K.; Kunsch,C.; Sundell,C.L.; Parthasarathy,S.; Saxena,U.; Sikorski,J.A.; Wasserman,M.A.
参考来源:Bioorg Med Chem Lett 2002,12(18),2545
合成路线:Esterification of probucol (I) with succinic anhydride (II) in the presence of NaH afforded the title monosuccinate ester,which was separated from the unreacted probucol (I) and the corresponding disuccinate ester by column chromatography.Esterification of (I) was also reported in the presence of other bases,such as potassium tert-butoxide,KOH,DMAP and DABCO.
参考文献标题:AGI-1067
文献作者:Sorbera,L.A.; Castar,J.
参考来源:Drugs Fut 2003,28(5),421
产品链接: CAS No. 216167-82-7››