Properties: The mixture is a white solid. Sol in water. Practically insol in most organic solvents. pKa in 66% aq DMF: 6.2, 8.2, 10.1, 13.3. Stable in aq soln at pH 4-8; unstable in strongly acidic or strongly basic solns.
pKa: pKa in 66% aq DMF: 6.2, 8.2, 10.1, 13.3
Derivative Type: Disulfate
CAS Registry Number: 1405-36-3
Trademarks: Caprocin (Lilly); Ogostal (Lilly)
Properties: Solubility data: March, Weiss, J. Assoc. Off. Anal. Chem.
50, 457 (1967). LD50 in mice, rats (mg/kg): 250, 325 i.v.; 514, 1191 s.c. (Welles).
Toxicity data: LD50 in mice, rats (mg/kg): 250, 325 i.v.; 514, 1191 s.c. (Welles)
Derivative Type: Capreomycin IA
CAS Registry Number: 37280-35-6
Percent Composition: C 44.90%, H 6.63%, N 29.32%, O 19.14%
Properties: mp 246-248° (dec). [a]D22 -21.9° (c = 0.5 in water). uv max (0.1N HCl): 269 nm (e 24000); (H2O): 268 nm (e 23900); (0.1N NaOH): 287 nm (e 15900) (all for hydrochloride ethanolate).
Melting point: mp 246-248° (dec)
Optical Rotation: [a]D22 -21.9° (c = 0.5 in water)
Absorption maximum: uv max (0.1N HCl): 269 nm (e 24000)
Derivative Type: Capreomycin IB
CAS Registry Number: 33490-33-4
Percent Composition: C 46.00%, H 6.79%, N 30.04%, O 17.16%
Properties: mp 253-255° (dec). [a]D22 -44.6° (c = 0.5 in water). uv max (0.1N HCl): 268 nm (e 22700); (H2O): 268 nm (e 22300); (0.1N NaOH): 290 nm (e 14400) (all for hydrochloride ethanolate).
Melting point: mp 253-255° (dec)
Optical Rotation: [a]D22 -44.6° (c = 0.5 in water)
Absorption maximum: uv max (0.1N HCl): 268 nm (e 22700)
NOTE:
Capreomycin IIA,
capreomycin IIB. Structures corresp to capreomycins IA and IB but lack b-lysine residues.
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Antibiotics); Polypeptides; Antibacterial (Tuberculostatic).
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