Properties: Crystals from alcohol + ether, mp 235-238° (dec). Soly (g/100 ml) 25°: acetone 0, isopropanol 0.09, ethanol 0.89, methanol 8.5, water 65.5. LD50 in rats (mg/kg): 96 i.v. (Fleisher). LD50 in rabbits (mg/kg): 95 i.v.; LD50 in mice (mg/kg): 115 i.v., 205 i.p., 4100 orally (Ellin, Wills).
Melting point: mp 235-238° (dec)
Toxicity data: LD50 in rats (mg/kg): 96 i.v. (Fleisher); LD50 in rabbits (mg/kg): 95 i.v.; LD50 in mice (mg/kg): 115 i.v., 205 i.p., 4100 orally (Ellin, Wills)
Derivative Type: Pralidoxime iodide
CAS Registry Number: 94-63-3
Additional Names: 2-Pyridine aldoxime methiodide; 2-PAM
Percent Composition: C 31.84%, H 3.44%, I 48.06%, N 10.61%, O 6.06%
Properties: Yellow crystals from alcohol, mp 225-226°. Soly at 25°: 48 mg/ml. Very sol in water, fairly sol in hot alcohol, poorly sol in cold alcohol. Insol in ether, acetone. LD50 in mice (mg/kg): 140-178 i.v., 136-260 i.p., 290-340 s.c., 1500-4000 orally (Ellin, Wills).
Melting point: mp 225-226°
Toxicity data: LD50 in mice (mg/kg): 140-178 i.v., 136-260 i.p., 290-340 s.c., 1500-4000 orally (Ellin, Wills)
Derivative Type: Pralidoxime mesylate
CAS Registry Number: 154-97-2
Trademarks: Contrathion (RPR)
Percent Composition: C 41.37%, H 5.21%, N 12.06%, O 27.55%, S 13.81%
Properties: Very hygroscopic crystals from ethanol, mp 155°. pKa 8.0. Soly in water: 1 g in 2 ml. LD50 in mice (mg/kg): 118-122 i.v., 216 i.p., 3700 orally; in rats (mg/kg): 109 i.v., 262 i.p. (Ellis, Wills).
Melting point: mp 155°
pKa: pKa 8.0
Toxicity data: LD50 in mice (mg/kg): 118-122 i.v., 216 i.p., 3700 orally; in rats (mg/kg): 109 i.v., 262 i.p. (Ellis, Wills)
Therap-Cat: Antidote (nerve gases and organophosphate insecticide poisoning.)
Keywords: Cholinesterase Reactivator; Antidote (Organophosphate Poisoning).
产品链接: 51-15-0››