Properties: Crystals from ethyl acetate, mp 146-148°. Also reported as mp 150-152° (Caplar). Freely sol in methanol; sol in acetic acid, DMSO; sparingly sol in 96% ethanol; slightly sol in water, isopropanol; very slightly sol in acetone, dioxane. Practically insol in acetonitrile, ethylacetate, chloroform. pKa 9.6. Partition coefficient (n-octanol/phosphate buffer): 0.008 (pH 7.0); 0.052 (pH 8.0). Dipole moment: 5.71 ±0.20 D at 20° in propionic acid. uv max (methanol): 225, 275, 283 nm. LD50 in mice, rats (mg/kg): 2000, 3000 orally; 98.7, 59.24 i.v. (Fitzgerald).
Melting point: mp 146-148°; mp 150-152° (Caplar)
pKa: pKa 9.6
Log P: Partition coefficient (n-octanol/phosphate buffer): 0.008 (pH 7.0); 0.052 (pH 8.0)
Absorption maximum: uv max (methanol): 225, 275, 283 nm
Toxicity data: LD50 in mice, rats (mg/kg): 2000, 3000 orally; 98.7, 59.24 i.v. (Fitzgerald)
Therap-Cat: Antihypertensive, antianginal, antiarrhythmic (class II).
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.
产品链接: 29122-68-7››