Derivative Type: Polifeprosan 20
Literature References: High mol wt polymer consisting of bis(p-carboxyphenoxy)propane and sebacic acid in a 20:80 ratio. Mol wt 20,000-200,000. Prepn: A. J. Domb, R. S. Langer,
EP
266603; eidem,
US
4757128 (both 1988 to MIT); eidem, J. Polym. Sci.
25, 3373 (1987).
Properties: White solid, mp 68°. Viscosity (in chloroform at 23°): 0.92 dl/g. Soly (g/100ml): 20 in chloroform; <1 in hexane.
Melting point: mp 68°
Derivative Type: Gliadel
Literature References: Polifeprosan 20 combined with carmustine, q.v., in an implantable wafer. Prepn and characterization of polymer-drug matrix: W. Dang et al., Pharm. Res.
13, 683 (1996); A. J. Domb et al., ibid.
16, 762 (1999). Clinical trial of surgically implanted wafer for malignant gliomas: H. Brem et al., Lancet
345, 1008 (1995); S. Valtonen et al., Neurosurgery
41, 44 (1997).
Use: Pharmaceutic aid for controlled release drug delivery.
产品链接: 90409-78-2››