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Bunitrolol CAS Registry Number: 34915-68-9 布诺洛尔

CAS Name: 2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]benzonitrile
Additional Names: o-[3-(tert-butylamino)-2-hydroxypropoxy]benzonitrile; 1-(2-cyanophenoxy)-2-hydroxy-3-tert-butylaminopropanePercent Composition: C 67.71%, H 8.12%, N 11.28%, O 12.89%

📌 参考资料/链接：
Literature References: b-Adrenergic blocker. Prepn: H. Koeppe et al., ZA 6803783; eidem, US 3541130 (1968, 1970 both to Boehringer, Ing.). Pharmacology: T. Kimura, Experientia 28, 813 (1972). Studies on absorption, distribution, metabolism, excretion in rats and mice: T. Suzuki, T. Rikihisa, Arzneim.-Forsch. 29, 1707 (1979). Clinical studies: A. Reale et al., J. Int. Med. Res. 4, 338 (1976); J. J. C. Jonker et al., Arzneim.-Forsch. 31, 1140 (1981). Toxicology study: M. Kanda et al., Oyo Yakuri 9, 457, 465, 499 (1975), C.A. 83, 172616 (1975).

📄 详细内容

Derivative Type: Hydrochloride
CAS Registry Number: 23093-74-5
Trademarks: Betriol (Boehringer, Ing.); Stresson (Boehringer, Ing.)
Percent Composition: C 59.05%, H 7.43%, N 9.84%, O 11.24%, Cl 12.45%
Properties: Crystals from ethanol, mp 163-165°. LD50 in mice, rats (mg/kg): 1344-1440, 639-649 orally; 264-265, 222-225 i.p. (Kanda).
Melting point: mp 163-165°
Toxicity data: LD50 in mice, rats (mg/kg): 1344-1440, 639-649 orally; 264-265, 222-225 i.p. (Kanda)
Therap-Cat: Antihypertensive, antiarrhythmic, antianginal.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.
产品链接: 34915-68-9››

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