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Pronethalol CAS Registry Number: 54-80-8 (+/-)-前萘洛尔

CAS Name: a-[[(1-Methylethyl)amino]methyl]-2-naphthalenemethanol
Additional Names: a-[(isopropylamino)methyl]-2-naphthalenemethanol; [2-hydroxy-2-(2-naphthyl)ethyl]isopropylamine; 2-isopropylamino-1-(2-naphthyl)ethanol; 1-(2'-naphthyl)-2-isopropylaminoethanol; nethalide
Percent Composition: C 78.56%, H 8.35%, N 6.11%, O 6.98%

📌 参考资料/链接：
Literature References: b-Adrenergic blocker. Prepd by reduction of 2-naphthacyl bromide with NaBH4 followed by reaction with isopropylamine: Stephenson, GB 909357 (1962 to ICI). Pharmacology: Black et al., Br. J. Pharmacol. Chemother. 25, 577 (1965). Carcinogenicity in mice: R. Howe, Nature 207, 594 (1965). Metabolism: W. G. Stillwell, M. G. Horning, Res. Commun. Chem. Pathol. Pharmacol. 9, 601 (1974).

📄 详细内容

Properties: Crystals, mp 108°.
Melting point: mp 108°
Derivative Type: Hydrochloride
CAS Registry Number: 51-02-5Trademarks: Alderlin (Zeneca)
Percent Composition: C 67.79%, H 7.58%, N 5.27%, O 6.02%, Cl 13.34%
Properties: Crystals, mp 184°. LD50 in mice (mg/kg): 512 orally, 46 i.v. (Black).
Melting point: mp 184°
Toxicity data: LD50 in mice (mg/kg): 512 orally, 46 i.v. (Black)
Therap-Cat: Antianginal; antiarrhythmic; antihypertensive.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Arylethanolamine Derivatives.
产品链接: 54-80-8››

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