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Fenoterol CAS Registry Number: 13392-18-2 非诺特罗

CAS Name: 5-[1-Hydroxy-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-1,3-benzenediol
Additional Names: 3,5-dihydroxy-a-[[(p-hydroxy-a-methylphenethyl)amino]methyl]benzyl alcohol; 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-[(4-hydroxyphenyl)isopropylamino]ethane; 1-(p-hydroxyphenyl)-2-[[b-hydroxy-b-(3',5'-dihydroxyphenyl)]ethyl]aminopropanePercent Composition: C 67.31%, H 6.98%, N 4.62%, O 21.10%

📌 参考资料/链接：
Literature References: b2-Adrenergic agonist. Prepn and sepn of stereoisomers: BE 640433; Zelle et al., US 3341593 (1962, 1967 to Boehringer, Ing.). Pharmacology: Schuster, Baum, Arzneim.-Forsch. 19, 1905 (1969); O'Donnell, Eur. J. Pharmacol. 12, 35 (1970). Toxicity: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Metabolism in mice: S. Kojima et al., Arzneim.-Forsch. 30, 959 (1980). HPLC determn in plasma: S. Kramer, G. Blaschke, J. Chromatogr. B 751, 169 (2001). Clinical evaluation: Tweel, Ann. Allergy 29, 142 (1971); Rebuck, Saunders, Med. J. Aust. 1, 225 (1972). Comparison with ritodrine in preterm labor: J. Gerris et al., Eur. J. Clin. Pharmacol. 18, 443 (1980). Review of pharmacology and therapeutic efficacy: R. C. Heel et al., Drugs 15, 3-32 (1978); N. Svedmyr, Pharmacotherapy 5, 109-126 (1985).

📄 详细内容

Derivative Type: Hydrobromide
CAS Registry Number: 1944-12-3Trademarks: Airum (Promeco); Berotec (Boehringer, Ing.); Dosberotec (Boehringer, Ing.); Partusisten (Boehringer, Ing.)
Percent Composition: C 53.14%, H 5.77%, N 3.65%, O 16.65%, Br 20.79%
Properties: Crystals from methanol-ether, mp 222-223°. LD50 in mice (mg/kg): 1100 s.c.; 1990 orally (Goldenthal).
Melting point: mp 222-223°
Toxicity data: LD50 in mice (mg/kg): 1100 s.c.; 1990 orally (Goldenthal)
Derivative Type: Hydrochloride
CAS Registry Number: 1944-10-1
Percent Composition: C 60.09%, H 6.53%, N 4.12%, O 18.83%, Cl 10.43%
Properties: mp 183° (acetonitrile-ether).
Melting point: mp 183° (acetonitrile-ether)
Therap-Cat: Bronchodilator; tocolytic.
Keywords: ?Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives; Tocolytic.
产品链接: 13392-18-2››

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