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Dobutamine CAS Registry Number: 34368-04-2 多巴酚丁胺

CAS Name: 4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]-1,2-benzenediol
Additional Names: (±)-4-[2-[[3-(p-hydroxyphenyl)-1-methylpropyl]amino]ethyl]pyrocatechol; 3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-b-phenylethylaminePercent Composition: C 71.73%, H 7.69%, N 4.65%, O 15.93%

📌 参考资料/链接：
Literature References: b1-Adrenergic agonist; derivative of dopamine, q.v. Prepn: R. R. Tuttle, J. Mills, DE 2317710; eidem, US 3987200 (1973, 1976 to Lilly). Pharmacology: R. Weber, R. R. Tuttle in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1977) pp 109-124; E. H. Sonnenblick et al., N. Engl. J. Med. 300, 17 (1979). Comprehensive description: R. H. Bishara, H. B. Long, Anal. Profiles Drug Subs. 8, 139-158 (1979).

📄 详细内容

Derivative Type: Hydrochloride
CAS Registry Number: 49745-95-1
Trademarks: Inotrex (obsolete) (Lilly); Dobutrex (Lilly)
Percent Composition: C 63.99%, H 7.16%, N 4.15%, O 14.21%, Cl 10.49%
Properties: Crystals, mp 184-186°. uv max (methanol): 281, 223 nm (e 4768, 14400). pKa 9.45. Rapidly oxidized at pH 11-13. LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle).
Melting point: mp 184-186°
pKa: pKa 9.45
Absorption maximum: uv max (methanol): 281, 223 nm (e 4768, 14400)
Toxicity data: LD50 i.v. in mice: ~73 mg/kg (Weber, Tuttle)
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic.
产品链接: 34368-04-2››

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