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Racecadotril CAS Registry Number: 81110-73-8 消旋卡多曲

CAS Name: N-[2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine phenylmethyl ester
Additional Names: N-[(R,S)-3-acetylthio-2-benzylpropanoyl]glycine benzyl ester; acetorphan
Trademarks: Hidrasec (GSK); Tiorfan (Bioprojet)
Percent Composition: C 65.43%, H 6.01%, N 3.63%, O 16.60%, S 8.32%

📌 参考资料/链接：
Literature References: Antisecretory enkephalinase inhibitor. Prepn: B. Roques et al., EP 38758 (1981); eidem, US 4513009 (1985 to Bioprojet). Pharmacology: J.-M. Lecomte et al., J. Pharmacol. Exp. Ther. 237, 937 (1986). Effect on intestinal transit: J. F. Bergmann et al., Aliment. Pharmacol. Ther. 6, 305 (1992). Clinical trial in acute diarrhea: P. Baumer et al., Gut 33, 753 (1992); in children: E. Salazar-Lindo et al., N. Engl. J. Med. 343, 463 (2000). Symposium on pharmacology and clinical experience: Aliment. Pharmacol. Ther. 13, Suppl. 6, 1-32 (1999). Review of clinical development: J.-C. Schwartz, Int. J. Antimicrob. Agents 14, 75-79 (2000); J. M. Lecomte, ibid. 81-87.

📄 详细内容

Properties: White crystals from ether mp 89°.
Melting point: mp 89°
Derivative Type: (S)-Form
CAS Registry Number: 112573-73-6
Additional Names: Ecadotril; sinorphanPercent Composition: C 65.43%, H 6.01%, N 3.63%, O 16.60%, S 8.32%
Literature References: Prepn: P. Duhamel et al.,
EP
318377; eidem,
US
5208255 (1989, 1993 both to Bioprojet); and pharmacology: B. Giros et al., J. Pharmacol. Exp. Ther.
243, 666 (1987). Clinical effect on plasma ANP levels in CHF: J. C. Kahn et al., Lancet
335, 118 (1990); on renal function: F. Schmitt et al., Am. J. Physiol.
267, F20 (1994). Clinical trial in heart failure: C. M. O'Connor et al., Am. Heart J.
138, 1140 (1999); J. G. F. Cleland, K. Swedberg, Lancet
351, 1657 (1998).
Properties: mp 71°. [a]D25 -24.1° (c = 1.3 in methanol). LD50 i.v. in mice: 100 mg/kg (Duhamel, 1993).
Melting point: mp 71°
Optical Rotation: [a]D25 -24.1° (c = 1.3 in methanol)
Toxicity data: LD50 i.v. in mice: 100 mg/kg (Duhamel, 1993)
Therap-Cat: Antidiarrheal.
Keywords: Antidiarrheal; Neutral Endopeptidase Inhibitor.
产品链接: 81110-73-8››

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