Pentosan Polysulfate CAS Registry Number: 37300-21-3 聚戊糖多硫醇

CAS Name: Xylan hydrogen sulfate
Additional Names: xylan polysulfateLiterature References: Semi-synthetic sulfated polyanion composed of b-D-xylopyranose residues with properties similar to heparin, q.v. Mol wt ranges from 1500 to 5000. Prepn:
CH
293566 (1953 to Wander), C.A.
49, 1787h (1955). Anticoagulant activity: B. Paramelle, Therapie
17, 719 (1962); J.-B., Dureux et al., ibid.
19, 879 (1964). Pharmacokinetics: R. Taugner et al., Arch. Int. Pharmacodyn.
189, 250 (1971). Effects on aggregation of human blood platelets: G. Kindness et al., Thromb. Res.
16, 97 (1979). Comparison of pentosan polysulfate with heparin: C. Soria et al., ibid.
19, 455 (1980); M. Ryde et al., ibid.
23, 435 (1981); A.-M. Fischer et al., Thromb. Haemostasis
47, 104, 109 (1982). Mechanism of antiadherence activity in urinary bladder: C. L. Parsons et al., Science
208, 605 (1980); eidem, Infect. Immun.
27, 876 (1980). Clinical trials in interstitial cystitis: A. Fritjofsson et al., J. Urol.
138, 508 (1987); S. G. Mulholland et al., Urology
6, 552 (1990).