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Dihydralazine CAS Registry Number: 484-23-1 双肼屈嗪

CAS Name: 2,3-Dihydro-1,4-phthalazinedione dihydrazone
Additional Names: 1,4-dihydrazinophthalazine
Percent Composition: C 50.52%, H 5.30%, N 44.18%

📌 参考资料/链接：
Literature References: Vasodilator. Prepn: J. Druey, US 2484785 (1949 to Ciba); J. Druey, B. H. Ringier, Helv. Chim. Acta 34, 195 (1951); Zerweck, Kunze, US 2786839 (1957 to Cassella Farbw.). Pharmacology: P. A. Van Zwieten, Arzneim.-Forsch. 18, 79 (1968). Mechanism of action: I. W. Reimann et al., Clin. Sci. 61, 319s (1981); eidem, Clin. Exp. Pharmacol. Physiol. 12, 79 (1985). Cerebrovascular effects in rats: L. M. Auer et al., Acta Med. Scand. Suppl. 678, 73 (1983); D. I. Barry et al., Stroke 15, 102 (1984). Hemodynamic responses in man: G. G. Belz, Clin. Pharmacol. Ther. 37, 48 (1985). Clinical studies: A. Salvadeo et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 19, 372 (1981); P. I. Salmela et al., Ann. Clin. Res. 13, 433 (1981). Toxicity data: G. Steiner et al., J. Med. Chem. 24, 59 (1981).

📄 详细内容

Properties: Orange needles from water, dec about 180°. LD50 i.p. in rats: 1084 mmol/kg (Steiner).
Toxicity data: LD50 i.p. in rats: 1084 mmol/kg (Steiner)
Derivative Type: Sulfate
CAS Registry Number: 7327-87-9
Trademarks: Pressunic (Unipharm)
Percent Composition: C 33.33%, H 4.20%, N 29.15%, S 11.12%, O 22.20%
Properties: Needles, dec 233°.
Derivative Type: Sulfate hemipentahydrate
Trademarks: Depressan (OPW); Dihyzin (Henning); Nepresol (Novartis); Népressol (Novartis)
Derivative Type: Methanesulfonate
Additional Names: Dihydralazine mesylate
Trademarks: Nepresol Inject (Novartis)
Percent Composition: C 37.75%, H 4.93%, N 29.35%, S 11.20%, O 16.76%
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Hydrazines/Phthalazines.
产品链接: 484-23-1››

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