网站主页>>>项目整合精选>>>项目整合精选>>>Monatepil CAS Registry Number: 103377-41-9 1-哌嗪丁酰胺,N-(6,11-二氢二苯并[b,e]噻庚英-11-基)-4-(4-氟苯基)-

Monatepil CAS Registry Number: 103377-41-9 1-哌嗪丁酰胺,N-(6,11-二氢二苯并[b,e]噻庚英-11-基)-4-(4-氟苯基)-

CAS Name: N-(6,11-Dihydrodibenzo[b,e]thiepin-11-yl)-4-(4-fluorophenyl)-1-piperazinebutanamide
Additional Names: 11-[4-[4-(4-fluorophenyl)-1-piperazinyl]butyrylamino]-6,11-dihydrodibenzo[b,e]thiepin
Percent Composition: C 70.71%, H 6.36%, F 3.99%, N 8.83%, O 3.36%, S 6.74%

📌 参考资料/链接：
Literature References: Tricyclic calcium channel blocker with a1-adrenoceptor antagonist activity. Prepn: H. Uno et al., WO 8601203; eidem, US 4749703 (1986, 1988 both to Dainippon); M. Kurokawa et al., J. Med. Chem. 34, 927 (1991). HPLC determn in plasma: M. Kurono et al., J. Chromatogr. 532, 175 (1990). Review of pharmacology: H. Takeuchi et al., Cardiovasc. Drug Rev. 12, 254-269 (1994). Series of articles on pharmacology and clinical effect in hypertension and hyperlipidemia: Am. J. Hypertens. 7 (No. 10, pt. 2), 131S-166S (1994).

📄 详细内容

Properties: Crystals from chloroform + n-hexane, mp 194-194.5°.
Melting point: mp 194-194.5°
Derivative Type: Maleate
CAS Registry Number: 103379-03-9Percent Composition: C 64.96%, H 5.79%, F 3.21%, N 7.10%, O 13.52%, S 5.42%
Properties: Colorless crystals from ethanol, mp 149-150°. Sol in acetic acid, dimethylformaldehyde, methanol; sparingly sol in ethanol, chloroform, acetic anhydride, acetone. Practically insol in water, ether. LD50 in mice (g/kg): 1 i.p.; 4 orally (Uno).
Melting point: mp 149-150°
Toxicity data: LD50 in mice (g/kg): 1 i.p.; 4 orally (Uno)
Therap-Cat: Antihypertensive.
Keywords: a-Adrenergic Blocker; Antihypertensive; Calcium Channel Blocker.
Status: This monograph has been retired and is no longer subject to revision or update.
产品链接: 103377-41-9››

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