Zonisamide CAS Registry Number: 68291-97-4 唑尼沙胺

📌 参考资料/链接：
Literature References: Sulfonamide antiseizure agent; blocks repetitive firing of voltage-sensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Prepn: H. Uno et al., JP Kokai 78 77057; eidem, US 4172896 (1978, 1979 both to Dainippon); eidem, J. Med. Chem. 22, 180 (1979). Pharmacology and toxicity: Y. Masuda et al., Arzneim.-Forsch. 30, 477 (1980). Mode of action study: T. Ito et al., ibid. 603. HPLC determn in serum: U. Juergens, J. Chromatogr. 385 233 (1987). Clinical trial in epilepsy: D. Schmidt et al., Epilepsy Res. 15, 67 (1993). Review of neuropharmacology: E. J. Hammond et al., Gen. Pharmacol. 18, 303 (1987); of pharmacokinetics and therapeutic potential: D. H. Peters, E. M. Sorkin, Drugs 45, 760-787 (1993); of pharmacokinetics and mechanism of action: I. E. Leppik, Seizure 13S, S5-S9 (2004).