Gemfibrozil CAS Registry Number: 25812-30-0 吉非罗齐
CAS Name: 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
Additional Names: 2,2-dimethyl-5-(2,5-xylyloxy)valeric acidTrademarks: Decrelip (Ferrer); Genlip (Teofarma); Gevilon (Pfizer); Lipozid (Pfizer); Lipur (Pfizer); Lopid (Pfizer)
Percent Composition: C 71.97%, H 8.86%, O 19.17%
📌 参考资料/链接：
Literature References: Serum lipid regulating agent. Prepn: P. L. Creger, DE 1925423; eidem, US 3674836 (1969, 1972, both to Parke, Davis). Production: O. P. Goel, US 4126637 (1978 to Warner-Lambert). Pharmacology: A. H. Kissebach et al., Atherosclerosis 24, 199 (1976); M. T. Kahonen et al., ibid. 32, 47 (1979). Series of articles on metabolism, clinical pharmacology, kinetics and toxicology: Proc. R. Soc. Med. 69, Suppl 2, 1-120 (1976). Toxicity data: S. M. Kurtz et al., ibid. 15. Clinical trial in hyperlipidemia: J. E. Lewis et al., Pract. Cardiol. 9, 99 (1983). Clinical reduction of cardiovascular risk in patients with low HDL levels: H. B. Rubins et al., N. Engl. J. Med. 341, 410 (1999).
📄 详细内容
Properties: Crystals from hexane, mp 61-63°. bp0.02 158-159°. LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz).
Melting point: mp 61-63°
Boiling point: bp0.02 158-159°
Toxicity data: LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.
产品链接: 25812-30-0››